The US-Japan alliance sits at a crucial historical juncture as globalization recedes and China’s international stature grows, with technological and geoeconomic competition at the core. The world is shifting from a technoglobalist-oriented economic and innovation framework premised on reducing barriers to trade, investment, and supply chain development amid harmonized multilateral standards. The technonationalist framework taking its place is prompting countries to intervene more frequently in trade and technological affairs to give their own high-tech industry leaders an advantage over those of other countries. The coronavirus pandemic and subsequent acceleration of nations adopting digital commerce and communications has raised the stakes for this transition. So has a new economic sanctions regime designed to isolate and punish Russia for its brutal invasion of Ukraine.